{"product_id":"9783319649177","title":"Parameter Advising for Multiple Sequence Alignment","description":"\u003cp\u003eThis book develops a new approach called \u003ci\u003eparameter advising\u003c\/i\u003e for finding a parameter setting for a sequence aligner that yields a quality alignment of a given set of input sequences. In this framework, a parameter\u003ci\u003e advisor\u003c\/i\u003e is a procedure that automatically chooses a parameter setting for the input, and has two main ingredients:\u003c\/p\u003e    \u003cp\u003e(a)         the \u003ci\u003eset \u003c\/i\u003eof parameter choices considered by the advisor, and\u003c\/p\u003e  \u003cp\u003e(b)         an \u003ci\u003eestimator\u003c\/i\u003e of alignment accuracy used to rank alignments produced by the aligner.\u003c\/p\u003e    \u003cp\u003eOn coupling a parameter advisor with an aligner, once the advisor is trained in a learning phase, the user simply inputs sequences to align, and receives an output alignment from the aligner, where the advisor has automatically selected the parameter setting.\u003c\/p\u003e    \u003cp\u003eThe chapters first lay out the foundations of parameter advising, and then cover applications and extensions of advising. The content\u003c\/p\u003e    \u003cp\u003e•   examines formulations of parameter advising and their \u003ci\u003ecomputational complexity\u003c\/i\u003e,\u003c\/p\u003e  \u003cp\u003e•   develops methods for learning good \u003ci\u003eaccuracy estimators\u003c\/i\u003e,\u003c\/p\u003e  \u003cp\u003e•   presents approximation algorithms for finding good sets of \u003ci\u003eparameter choices\u003c\/i\u003e, and \u003c\/p\u003e  \u003cp\u003e•   assesses \u003ci\u003esoftware implementations\u003c\/i\u003e of advising that perform well on real biological data.\u003c\/p\u003e    \u003cp\u003eAlso explored are applications of parameter advising to\u003c\/p\u003e    \u003cp\u003e•   \u003ci\u003eadaptive local realignment\u003c\/i\u003e, where advising is performed on local regions of the sequences to automatically adapt to varying mutation rates, and\u003c\/p\u003e  \u003cp\u003e•   \u003ci\u003eensemble alignment\u003c\/i\u003e, where advising is applied to an ensemble of aligners to effectively yield a new aligner of higher quality than the individual aligners in the ensemble.\u003c\/p\u003e    \u003cp\u003eThe book concludes by offering future directions in advising research.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePublication Year: \u003c\/strong\u003e2017\u003cbr\u003e\u003cstrong\u003eImprint: \u003c\/strong\u003eSpringer International Publishing\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003eFormat: H\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003eWeight (Gram): 474\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Dan DeBlasio","offers":[{"title":"Default Title","offer_id":41246482104498,"sku":"9783319649177","price":1991337.25,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0502\/5382\/4178\/products\/3319649175.01_SCLZZZZZZZ.jpg?v=1635648422","url":"https:\/\/readabook.store\/en-id\/products\/9783319649177","provider":"READABOOK BY ALKEM","version":"1.0","type":"link"}