{"product_id":"9781461482888","title":"Gadd45 Stress Sensor Genes","description":"Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b \u0026amp; Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear\/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently \u0026amp; exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation \u0026amp; repair, apoptosis, cell survival, genomic stability, inflammation, \u0026amp; in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure\/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress\/stimulus.  Protein partners include cdc2\/cyclinB1, p21, the p38\/JNK stress induced kinase pathways, and PCNA\/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors \u0026amp; the molecular pathways involved.  \u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePublication Year: \u003c\/strong\u003e2013\u003cbr\u003e\u003cstrong\u003eImprint: \u003c\/strong\u003eSpringer New York\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003eFormat: H\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003eWeight (Gram): 3435\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Dan A. Liebermann","offers":[{"title":"Default Title","offer_id":41278915215538,"sku":"9781461482888","price":218.39,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0502\/5382\/4178\/products\/1461482887.01_SCLZZZZZZZ.jpg?v=1636249321","url":"https:\/\/readabook.store\/products\/9781461482888","provider":"READABOOK BY ALKEM","version":"1.0","type":"link"}