{"product_id":"9783030166267","title":"Cancer Stem Cell Resistance to Targeted Therapy","description":"\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book represents an up-dated summary of the state of the art of the characterization of cancer stem cell\/ cancer initiating cell (CSC\/CIC) properties.  An overview of the definition and biological properties of CSCs\/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs\/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs\/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. \u003c\/p\u003e\n\n\u003cp\u003eThis book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs\/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs\/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePublication Year: \u003c\/strong\u003e2019\u003cbr\u003e\u003cstrong\u003eImprint: \u003c\/strong\u003eSpringer International Publishing\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Cristina Maccalli","offers":[{"title":"Default Title","offer_id":41255990821042,"sku":"9783030166267","price":171.59,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0502\/5382\/4178\/products\/3030166260.01_SCLZZZZZZZ.jpg?v=1635866630","url":"https:\/\/readabook.store\/products\/9783030166267","provider":"READABOOK BY ALKEM","version":"1.0","type":"link"}